Dorian Gray - Devising a personalized risk stratification and holistic management for prevention of cognitive impairment in patients with different cardiovascular phenotypes

Project Website

Dorian Gray - Devising a personalized risk stratification and holistic management for prevention of cognitive impairment in patients with different cardiovascular phenotypes

Project Website
This image shows an elderly woman with long grey wavy hair and a blue floral shirt, sitting and facing to her right. In the center, between her joined hands, is a stylized icon of a human-like robot head, with lines and dots emanating from various points on the head, as if indicating a process of analysis or connection. The bottom of the image is framed by a purple and blue wave shape. This image could represent the interaction between technology and human experience, or the analysis of the human mind through technological means.

The DORIAN GRAY project investigates the complex link between Cardiovascular Diseases (CVD) and Mild Cognitive Impairment (MCI) in ageing populations. The main goal is to develop early, personalized, and scalable interventions to slow cognitive decline in patients with cardiovascular risk.Aligned with Horizon Europe’s plan for non-communicable disease (NCD) prevention, DORIAN GRAY focuses on:


The project brings together 25 European partners across academia, healthcare, research, and industry. The consortium’s expertise spans AI, neurology, cardiology, digital health, and behavioral sciences, creating a robust ecosystem for innovation in personalized preventive medicine.

Methodology and Innovation

The project integrates AI technologies and digital health tools to deliver a comprehensive and user-centered prevention model. It is structured into three main pillars:

  1. AI-Powered Risk StratificationPredictive models will leverage biomarkers, clinical imaging, and wearable data to identify early signs of MCI in patients with cardiovascular risk factors.
  2. PORTRAIT Digital Twin PlatformAn AI-based simulation platform modeling disease trajectories to tailor interventions. It continuously adapts to each patient’s evolving health status.
  3. MIRROR App – Coaching & ExergamingA mobile app using avatar-guided gamified sessions (exergames) that combine physical and cognitive training. It adapts to user progress to foster engagement and behavioral change.

Development


Expected Impacts


Research groups